Ontology highlight
ABSTRACT:
SUBMITTER: Chen B
PROVIDER: S-EPMC3675137 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Chen Bo B Xue Zheng Z Yang Guanghui G Shi Bingyang B Yang Ben B Yan Yuemin Y Wang Xue X Han Daishu D Huang Yue Y Dong Wenji W
PloS one 20130606 6
The mechanism by which Akt modulates stem cell homeostasis is still incompletely defined. Here we demonstrate that Akt phosphorylates special AT-rich sequences binding protein 1 (SATB1) at serine 47 and protects SATB1 from apoptotic cleavage. Meanwhile, Akt phosphorylates Oct4 at threonine 228 and Klf4 at threonine 399, and accelerates their degradation. Moreover, PI3K/Akt signaling enhances the binding of SATB1 to Sox2, thereby probably impairing the formation of Oct4/Sox2 regulatory complexes. ...[more]