Ontology highlight
ABSTRACT:
SUBMITTER: Lakhter AJ
PROVIDER: S-EPMC3675185 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
The Journal of investigative dermatology 20130131 9
The Bcl homology-3 (BH3)-only protein p53 upregulated modulator of apoptosis (PUMA) counters Bcl-2 family anti-apoptotic proteins and promotes apoptosis. Although PUMA is a key regulator of apoptosis, the post-transcriptional mechanisms that control PUMA protein stability are not understood. We show that a lysosome-independent activity of chloroquine (CQ) prevents degradation of PUMA protein, promotes apoptosis, and reduces the growth of melanoma xenografts in mice. Compared with wild-type PUMA, ...[more]