Ontology highlight
ABSTRACT:
SUBMITTER: Tsunematsu T
PROVIDER: S-EPMC3675325 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Tsunematsu Takaaki T Takihara Yoshihiro Y Ishimaru Naozumi N Pagano Michele M Takata Takashi T Kudo Yasusei Y
Nature communications 20130101
Geminin, an essential factor for DNA replication, directly binds to the licensing factor Cdt1 and inhibits pre-replicative complex formation to prevent re-replication. In G1, geminin levels are controlled by the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase complex, which targets geminin for proteasomal degradation to allow pre-replicative complex formation. Conversely, from S to G2, geminin is stabilized due to APC/C ubiquitin ligase complex inhibition, ensuring the inhibition o ...[more]