Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2.

ABSTRACT:

Background

The discovery of TCF7L2 as a global type 2 diabetes (T2D) gene has sparked investigations to explore the clinical utility of its variants for guiding the development of new diagnostic and therapeutic strategies. However, interpreting the resulting associations into function still remains unclear. Canonical Wnt signaling regulates β-catenin and its binding with TCF7L2, which in turn is critical for the production of glucagon-like peptide-1 (GLP-1). This study examines the role of a novel frame-shift insertion discovered in a conserved region of WNT16a, and it is proposed that this mutation affects T2D susceptibility in conjunction with gene variants in TCF7L2.

Results

Our results predicted that the insertion would convert the upstream open reading frame in the Wnt1

SUBMITTER: Howard EW 

PROVIDER: S-EPMC3675375 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature