Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Y
PROVIDER: S-EPMC3675877 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Zhu Yan Y Liang Chun C Chen Jin J Zong Liang L Chen Guang-Di GD Zhao Hong-Bo HB
Nature communications 20130101
Mammalian hearing relies upon active cochlear mechanics, which arises from outer hair cell electromotility and hair bundle movement, to amplify acoustic stimulations increasing hearing sensitivity and frequency selectivity. Here we describe the novel finding that gap junctions between cochlear supporting cells also have a critical role in active cochlear amplification in vivo. We find that targeted-deletion of connexin 26 in Deiters cells and outer pillar cells, which constrain outer hair cells ...[more]