Ontology highlight
ABSTRACT:
SUBMITTER: Spokoyny AM
PROVIDER: S-EPMC3675880 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Spokoyny Alexander M AM Zou Yekui Y Ling Jingjing J JJ Yu Hongtao H Lin Yu-Shan YS Pentelute Bradley L BL
Journal of the American Chemical Society 20130416 16
We report the discovery of a facile transformation between perfluoroaromatic molecules and a cysteine thiolate, which is arylated at room temperature. This new approach enabled us to selectively modify cysteine residues in unprotected peptides, providing access to variants containing rigid perfluoroaromatic staples. This stapling modification performed on a peptide sequence designed to bind the C-terminal domain of an HIV-1 capsid assembly polyprotein (C-CA) showed enhancement in binding, cell p ...[more]