Ontology highlight
ABSTRACT:
SUBMITTER: Berro R
PROVIDER: S-EPMC3676082 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Berro Reem R Yasmeen Anila A Abrol Ravinder R Trzaskowski Bartosz B Abi-Habib Sarya S Grunbeck Amy A Lascano Danny D Goddard William A WA Klasse Per Johan PJ Sakmar Thomas P TP Moore John P JP
Journal of virology 20130306 12
Small-molecule CCR5 inhibitors such as vicriviroc (VVC) and maraviroc (MVC) are allosteric modulators that impair HIV-1 entry by stabilizing a CCR5 conformation that the virus recognizes inefficiently. Viruses resistant to these compounds are able to bind the inhibitor-CCR5 complex while also interacting with the free coreceptor. CCR5 also interacts intracellularly with G proteins, as part of its signal transduction functions, and this process alters its conformation. Here we investigated whethe ...[more]