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The potential of stem cells as an in vitro source of red blood cells for transfusion.


ABSTRACT: Recent advances have increased excitement about the potential for therapeutic production of red blood cells (RBCs) in vitro. However, generation of RBCs in the large numbers required for transfusion remains a significant challenge. In this article, we summarize recent progress in producing RBCs from various cell sources, and discuss the hurdles that remain for translation into the clinical arena.

SUBMITTER: Migliaccio AR 

PROVIDER: S-EPMC3676433 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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The potential of stem cells as an in vitro source of red blood cells for transfusion.

Migliaccio Anna Rita AR   Whitsett Carolyn C   Papayannopoulou Thalia T   Sadelain Michel M  

Cell stem cell 20120201 2


Recent advances have increased excitement about the potential for therapeutic production of red blood cells (RBCs) in vitro. However, generation of RBCs in the large numbers required for transfusion remains a significant challenge. In this article, we summarize recent progress in producing RBCs from various cell sources, and discuss the hurdles that remain for translation into the clinical arena. ...[more]

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