Ontology highlight
ABSTRACT:
SUBMITTER: King GD
PROVIDER: S-EPMC3677209 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
King Gwendalyn D GD Chen CiDi C Huang Mickey M MM Zeldich Ella E Brazee Patricia L PL Schuman Eli R ER Robin Maxime M Cuny Gregory D GD Glicksman Marcie A MA Abraham Carmela R CR
The Biochemical journal 20120101 1
The absence of Klotho (KL) from mice causes the development of disorders associated with human aging and decreased longevity, whereas increased expression prolongs lifespan. With age, KL protein levels decrease, and keeping levels consistent may promote healthier aging and be disease-modifying. Using the KL promoter to drive expression of luciferase, we conducted a high-throughput screen to identify compounds that activate KL transcription. Hits were identified as compounds that elevated lucifer ...[more]