Ontology highlight
ABSTRACT:
SUBMITTER: Hall MP
PROVIDER: S-EPMC3677278 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Hall Megan P MP Nagel Roland J RJ Fagg W Samuel WS Shiue Lily L Cline Melissa S MS Perriman Rhonda J RJ Donohue John Paul JP Ares Manuel M
RNA (New York, N.Y.) 20130322 5
Alternative splicing contributes to muscle development, but a complete set of muscle-splicing factors and their combinatorial interactions are unknown. Previous work identified ACUAA ("STAR" motif) as an enriched intron sequence near muscle-specific alternative exons such as Capzb exon 9. Mass spectrometry of myoblast proteins selected by the Capzb exon 9 intron via RNA affinity chromatography identifies Quaking (QK), a protein known to regulate mRNA function through ACUAA motifs in 3' UTRs. We ...[more]