Ontology highlight
ABSTRACT:
SUBMITTER: Weber JK
PROVIDER: S-EPMC3677858 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Weber Jeffrey K JK Jack Robert L RL Pande Vijay S VS
Journal of the American Chemical Society 20130403 15
The extent to which glass-like kinetics govern dynamics in protein folding has been heavily debated. Here, we address the subject with an application of space-time perturbation theory to the dynamics of protein folding Markov state models. Borrowing techniques from the s-ensemble method, we argue that distinct active and inactive phases exist for protein folding dynamics, and that kinetics for specific systems can fall into either dynamical regime. We do not, however, observe a true glass transi ...[more]