Ontology highlight
ABSTRACT:
SUBMITTER: McDavid A
PROVIDER: S-EPMC3677889 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
McDavid Andrew A Crane Paul K PK Newton Katherine M KM Crosslin David R DR McCormick Wayne W Weston Noah N Ehrlich Kelly K Hart Eugene E Harrison Robert R Kukull Walter A WA Rottscheit Carla C Peissig Peggy P Stefanski Elisha E McCarty Catherine A CA Zuvich Rebecca Lynn RL Ritchie Marylyn D MD Haines Jonathan L JL Denny Joshua C JC Schellenberg Gerard D GD de Andrade Mariza M Kullo Iftikhar I Li Rongling R Mirel Daniel D Crenshaw Andrew A Bowen James D JD Li Ge G Tsuang Debby D McCurry Susan S Teri Linda L Larson Eric B EB Jarvik Gail P GP Carlson Chris S CS
PloS one 20130610 6
The feasibility of using imperfectly phenotyped "silver standard" samples identified from electronic medical record diagnoses is considered in genetic association studies when these samples might be combined with an existing set of samples phenotyped with a gold standard technique. An analytic expression is derived for the power of a chi-square test of independence using either research-quality case/control samples alone, or augmented with silver standard data. The subset of the parameter space ...[more]