Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC3678169 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Liu Yunhao Y Collins Caitlin C Kiosses William B WB Murray Ann M AM Joshi Monika M Shepherd Tyson R TR Fuentes Ernesto J EJ Tzima Ellie E
The Journal of cell biology 20130603 6
Hemodynamic forces regulate embryonic organ development, hematopoiesis, vascular remodeling, and atherogenesis. The mechanosensory stimulus of blood flow initiates a complex network of intracellular pathways, including activation of Rac1 GTPase, establishment of endothelial cell (EC) polarity, and redox signaling. The activity of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase can be modulated by the GTP/GDP state of Rac1; however, the molecular mechanisms of Rac1 activation by f ...[more]