Ontology highlight
ABSTRACT:
SUBMITTER: Sun MY
PROVIDER: S-EPMC3678369 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Sun Mary Y MY Habeck Jason M JM Meyer Katie M KM Koch Jill M JM Ramadoss Jayanth J Blohowiak Sharon E SE Magness Ronald R RR Kling Pamela J PJ
Pediatric research 20121130 3
<h4>Background</h4>Fetal growth restriction is reported to be associated with impaired placental iron transport. Transferrin receptor (TfR) is a major placental iron transporter in humans but has not been studied in sheep. TfR is regulated by both iron and nitric oxide (NO), the molecule produced by endothelial nitric oxide synthase (eNOS). We hypothesized that limited placental development downregulates both placental TfR and eNOS expression, thereby lowering fetal tissue iron.<h4>Methods</h4>A ...[more]