Ontology highlight
ABSTRACT:
SUBMITTER: Mayes MD
PROVIDER: S-EPMC3678376 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Current opinion in rheumatology 20121101 6
<h4>Purpose of review</h4>The last decade has seen enormous progress in understanding genetic associations of systemic sclerosis to explain the observed heritability. This review highlights the most recent findings and places them in the context of proposed functional roles.<h4>Recent findings</h4>Over 30 genes and gene regions have now been identified as scleroderma susceptibility loci. These include both human leukocyte antigen (HLA) and non-HLA genes, most of which involve immune-related path ...[more]