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Association of vitamin D receptor gene polymorphisms with pancreatic cancer: A pilot study in a North China Population.


ABSTRACT: Polymorphisms of the vitamin D receptor (VDR) gene may be a risk factor for pancreatic cancer (PC). We investigated the association of two single-nucleotide polymorphisms (SNPs) of the VDR gene with PC in age- and gender-matched patients and controls. PC (n=91) and healthy control (n=80) samples were genotyped for the FokI (rs2228570) and BsmI (rs1544410) polymorphisms using the PCR and restriction fragment length polymorphism (PCR-RFLP) method. Chi-square analysis was used to test for the overall association of VDR genotype with disease. There was a significant difference in the frequency of genotype FF between the PC patients and controls (Ptrend=0.009); however, the difference in frequency of genotype BB between the two groups was not significant (Ptrend=0.082). The difference between FF and Ff/ff frequency was significant (P=0.002). The two high-risk genotypes were ffbb and Ffbb, with an 11.66- and 6.42-fold increased risk of PC, respectively. VDR gene polymorphisms were important for the development of PC in this study population; however, further exploration of these findings and their implications are required.

SUBMITTER: Li L 

PROVIDER: S-EPMC3678656 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Association of vitamin D receptor gene polymorphisms with pancreatic cancer: A pilot study in a North China Population.

Li Lei L   Wu Bo B   Yang Libo L   Yin Guancheng G   Wei Wei W   Sui Shujing S   Liu Jiyong J  

Oncology letters 20130228 5


Polymorphisms of the vitamin D receptor (VDR) gene may be a risk factor for pancreatic cancer (PC). We investigated the association of two single-nucleotide polymorphisms (SNPs) of the VDR gene with PC in age- and gender-matched patients and controls. PC (n=91) and healthy control (n=80) samples were genotyped for the <i>Fok</i>I (rs2228570) and <i>Bsm</i>I (rs1544410) polymorphisms using the PCR and restriction fragment length polymorphism (PCR-RFLP) method. Chi-square analysis was used to test  ...[more]

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