Ontology highlight
ABSTRACT:
SUBMITTER: Liu M
PROVIDER: S-EPMC3678716 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Liu Mingyu M Haenssler Eva E Uehara Tsuyoshi T Losick Vicki P VP Park James T JT Isberg Ralph R RR
Cell host & microbe 20120801 2
Successful pathogens have evolved to evade innate immune recognition of microbial molecules by pattern recognition receptors (PRR), which control microbial growth in host tissues. Upon Legionella pneumophila infection of macrophages, the cytosolic PRR Nod1 recognizes anhydro-disaccharide-tetrapeptide (anhDSTP) generated by soluble lytic transglycosylase (SltL), the predominant bacterial peptidoglycan degrading enzyme, to activate NF-κB-dependent innate immune responses. We show that L. pneumophi ...[more]