Ontology highlight
ABSTRACT:
SUBMITTER: Lim KJ
PROVIDER: S-EPMC3679022 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lim Ki Jung KJ Sung Bong Hyun BH Shin Ju Ri JR Lee Young Woong YW Kim Da Jung DJ Yang Kyung Seok KS Kim Sun Chang SC
PloS one 20130611 6
Cell-penetrating peptides (CPPs) have proven very effective as intracellular delivery vehicles for various therapeutics. However, there are some concerns about non-specific penetration and cytotoxicity of CPPs for effective cancer treatments. Herein, based on the cell-penetrating motif of an anticancer peptide, buforin IIb, we designed several CPP derivatives with cancer cell specificity. Among the derivatives, a 17-amino acid peptide (BR2) was found to have cancer-specificity without toxicity t ...[more]