Dataset Information
Clinical relevance of plasma prostaglandin F2? metabolite concentrations in patients with idiopathic pulmonary fibrosis.
Ontology highlight
ABSTRACT: Background
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology with few current treatment options. Recently, we determined an important role of prostaglandin F2? (PGF2?) in pulmonary fibrosis by using a bleomycin-induced pulmonary fibrosis model and found an abundance of PGF2? in bronchoalveolar lavage fluid of IPF patients. We investigated the role of PGF2? in human IPF by assessing plasma concentrations of 15-keto-dihydro PGF2?, a stable metabolite of PGF2?.Methods
We measured plasma concentrations of 15-keto-dihydro PGF2? in 91 IPF patients and compared these values with those of controls (n?=?25). We further investigated the relationships of plasma 15-keto-dihydro PGF2? concentrations with disease severity and mortality.Results
Plasma concentrations of 15-keto-dihydro PGF2? were significantly higher in IPF patients than controls (p<0.001). Plasma concentrations of this metabolite were significantly correlated with forced expiratory volume in 1 second (Rs [correlation coefficient]?=?-0.34, p?=?0.004), forced vital capacity (Rs?=?-0.33, p?=?0.005), diffusing capacity for carbon monoxide (Rs?=?-0.36, p?=?0.003), the composite physiologic index (Rs?=?0.40, p?=?0.001), 6-minute walk distance (Rs?=?-0.24, p?=?0.04) and end-exercise oxygen saturation (Rs?=?-0.25, p?=?0.04) when patients with emphysema were excluded. Multivariate analysis using stepwise Cox proportional hazards model showed that a higher composite physiologic index (relative risk?=?1.049, p?=?0.002) and plasma 15-keto-dihydro PGF2? concentrations (relative risk?=?1.005, p?=?0.002) were independently associated with an increased risk of mortality.Conclusions
We demonstrated significant associations of plasma concentrations of PGF2? metabolites with disease severity and prognosis, which support a potential pathogenic role for PGF2? in human IPF.
SUBMITTER: Aihara K
PROVIDER: S-EPMC3679025 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Clinical relevance of plasma prostaglandin F2α metabolite concentrations in patients with idiopathic pulmonary fibrosis.
PloS one 20130611 6
<h4>Background</h4>Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology with few current treatment options. Recently, we determined an important role of prostaglandin F2α (PGF2α) in pulmonary fibrosis by using a bleomycin-induced pulmonary fibrosis model and found an abundance of PGF2α in bronchoalveolar lavage fluid of IPF patients. We investigated the role of PGF2α in human IPF by assessing plasma concentrations of 15-keto-dihydro PGF2α, a stable metabolite of ...[more]
