Ontology highlight
ABSTRACT:
SUBMITTER: Gogliotti RG
PROVIDER: S-EPMC3679180 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Gogliotti Rocky G RG Lutz Cathleen C Jorgensen Michael M Huebsch Kimberly K Koh Sookyong S Didonato Christine J CJ
Neurobiology of disease 20110321 1
The SMN2 transgenic mouse, Tg(SMN2)89Ahmb, has emerged as the most widely used in spinal muscular atrophy (SMA) research. Here we clone the genomic integration site of the transgene and demonstrate it to be in intron 4 of the metabotropic glutamate receptor 7 (mGluR7) gene. We found that the integration of this transgene significantly reduced both mGluR7 mRNA and protein levels (24% and 9%, respectively). To determine if phenotypes associated with mGluR7 knockout mice were present in Tg(SMN2)89A ...[more]