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ABSTRACT:
SUBMITTER: Gallaher SD
PROVIDER: S-EPMC3679352 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Gallaher Sean D SD Berk Arnold J AJ
Journal of virological methods 20130426 1-2
Adenoviruses are employed in the study of cellular processes and as expression vectors used in gene therapy. The success and reproducibility of these studies is dependent in part on having accurate and meaningful titers of replication competent and helper-dependent adenovirus stocks, which is problematic due to the use of varied and divergent titration protocols. Physical titration methods, which quantify the total number of viral particles, are used by many, but are poor at estimating activity. ...[more]