Ontology highlight
ABSTRACT:
SUBMITTER: Al Tanoury Z
PROVIDER: S-EPMC3679380 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Al Tanoury Ziad Z Piskunov Aleksandr A Rochette-Egly Cécile C
Journal of lipid research 20130224 7
Vitamin A or retinol is arguably the most multifunctional vitamin in the human body, as it is essential from embryogenesis to adulthood. The pleiotropic effects of vitamin A are exerted mainly by one active metabolite, all-trans retinoic acid (atRA), which regulates the expression of a battery of target genes through several families of nuclear receptors (RARs, RXRs, and PPARβ/δ), polymorphic retinoic acid (RA) response elements, and multiple coregulators. It also involves extranuclear and nontr ...[more]