Ontology highlight
ABSTRACT:
SUBMITTER: Clasen BF
PROVIDER: S-EPMC3679400 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Clasen Berthil F F BF Krusenstjerna-Hafstrøm Thomas T Vendelbo Mikkel Holm MH Thorsen Kasper K Escande Carlos C Møller Niels N Pedersen Steen B SB Jørgensen Jens Otto L JO Jessen Niels N
Journal of lipid research 20130420 7
Growth hormone (GH) acutely stimulates lipolysis and fat oxidation, a process that operates postabsorptively and involves activation of the JAK-STAT pathway in the target tissue; no in vivo data exist regarding subsequent GH-regulated gene transcription. We obtained serum samples and muscle biopsies in human subjects before and 2 h after administration of a GH bolus. A significant (~75%) elevation in serum FFA levels was recorded post GH. Microarray identified 79 GH-regulated genes in muscle. Wi ...[more]