Unknown

Dataset Information

0

Crystal structure of AcrB complexed with linezolid at 3.5 A resolution.


ABSTRACT: AcrB is an inner membrane resistance-nodulation-cell division efflux pump and is part of the AcrAB-TolC tripartite efflux system. We have determined the crystal structure of AcrB with bound Linezolid at a resolution of 3.5 Å. The structure shows that Linezolid binds to the A385/F386 loops of the symmetric trimer of AcrB. A conformational change of a loop in the bottom of the periplasmic cleft is also observed.

SUBMITTER: Hung LW 

PROVIDER: S-EPMC3679416 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC2929978 | biostudies-literature
| S-EPMC2374193 | biostudies-literature
| S-EPMC3494952 | biostudies-other
| S-EPMC22628 | biostudies-literature
| S-EPMC2023878 | biostudies-literature
| S-EPMC2344114 | biostudies-literature
| S-EPMC6370903 | biostudies-literature
| S-EPMC2203289 | biostudies-literature
| S-EPMC3593067 | biostudies-literature
| S-EPMC6038453 | biostudies-literature