Ontology highlight
ABSTRACT:
SUBMITTER: Lui K
PROVIDER: S-EPMC3679486 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Lui Ki K An Jie J Montalbano Joanne J Shi Jingxue J Corcoran Chad C He Qin Q Sun Hong H Sheikh M Saeed MS Huang Ying Y
Journal of cell science 20130409 Pt 11
We had previously reported that RBEL1A, a novel Ras-like GTPase, was overexpressed in multiple human malignancies and that its depletion suppressed cell growth. However, the underlying molecular mechanism remained to be elucidated. Here we report that depletion of endogenous RBEL1A results in p53 accumulation due to increased p53 half-life whereas increased expression of RBEL1A reduces p53 levels under unstressed and genotoxic stress conditions. RBEL1A directly interacts with p53 and MDM2, and s ...[more]