Ontology highlight
ABSTRACT:
SUBMITTER: Jackman JE
PROVIDER: S-EPMC3680101 | biostudies-literature | 2013 Jan-Feb
REPOSITORIES: biostudies-literature
Jackman Jane E JE Alfonzo Juan D JD
Wiley interdisciplinary reviews. RNA 20121108 1
Following synthesis, tRNAs are peppered by numerous chemical modifications which may differentially affect a tRNA's structure and function. Although modifications affecting the business ends of a tRNA are predictably important for cell viability, a majority of modifications play more subtle structural roles that can affect tRNA stability and folding. The current trend is that modifications act in concert and it is in the context of the specific sequence of a given tRNA that they impart their dif ...[more]