Ontology highlight
ABSTRACT:
SUBMITTER: Denton PW
PROVIDER: S-EPMC3680353 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Denton Paul W PW Garcia J Victor JV
Trends in microbiology 20120412 6
Clinical trials testing microbicides and related biomedical interventions to block HIV transmissions have produced contradictory results and to date it is unclear why. Further elucidation of the molecular basis of mucosal HIV transmission and extensive pharmacokinetic and pharmacodynamic analyses are essential to implementing effective prevention strategies. Animal models are of critical importance to this effort and bone marrow-liver-thymus (BLT) humanized mice have recently emerged as a powerf ...[more]