Ontology highlight
ABSTRACT:
SUBMITTER: Jacot D
PROVIDER: S-EPMC3680736 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Jacot Damien D Daher Wassim W Soldati-Favre Dominique D
The EMBO journal 20130521 12
Members of the Apicomplexa phylum possess an organelle surrounded by four membranes, originating from the secondary endosymbiosis of a red alga. This so-called apicoplast hosts essential metabolic pathways. We report here that apicoplast inheritance is an actin-based process. Concordantly, parasites depleted in either profilin or actin depolymerizing factor, or parasites overexpressing the FH2 domain of formin 2, result in loss of the apicoplast. The class XXII myosin F (MyoF) is conserved acros ...[more]