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Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.

ABSTRACT: Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.

SUBMITTER: Obermoser G

PROVIDER: S-EPMC3681204 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.

Obermoser Gerlinde G Presnell Scott S Domico Kelly K Xu Hui H Wang Yuanyuan Y Anguiano Esperanza E Thompson-Snipes Luann L Ranganathan Rajaram R Zeitner Brad B Bjork Anna A Anderson David D Speake Cate C Ruchaud Emily E Skinner Jason J Alsina Laia L Sharma Mamta M Dutartre Helene H Cepika Alma A Israelsson Elisabeth E Nguyen Phuong P Nguyen Quynh-Anh QA Harrod A Carson AC Zurawski Sandra M SM Pascual Virginia V Ueno Hideki H Nepom Gerald T GT Quinn Charlie C Blankenship Derek D Palucka Karolina K Banchereau Jacques J Chaussabel Damien D

Immunity 20130401 4

Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the p ...[more]

PMID: 23601689

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Project description:BackgroundHealth-seeking behaviors change during pandemics and may increase with regard to illnesses with symptoms similar to the pandemic. The global reaction to COVID-19 may drive interest in vaccines for other diseases.ObjectivesOur study investigated the correlation between global online interest in COVID-19 and interest in CDC-recommended routine vaccines.Design, settings, measurementsThis infodemiology study used Google Trends data to quantify worldwide interest in COVID-19 and CDC-recommended vaccines using the unit search volume index (SVI), which estimates volume of online search activity relative to highest volume of searches within a specified period. SVIs from December 30, 2019 to March 30, 2020 were collected for "coronavirus (Virus)" and compared with SVIs of search terms related to CDC-recommended adult vaccines. To account for seasonal variation, we compared SVIs from December 30, 2019 to March 30, 2020 with SVIs from the same months in 2015 to 2019. We performed country-level analyses in ten COVID-19 hotspots and ten countries with low disease burden.ResultsThere were significant positive correlations between SVIs for "coronavirus (Virus)" and search terms for pneumococcal (R = 0.89, p < 0.0001) and influenza vaccines (R = 0.93, p < 0.0001) in 2020, which were greater than SVIs for the same terms in 2015-2019 (p = 0.005, p < 0.0001, respectively). Eight in ten COVID-19 hotspots demonstrated significant positive correlations between SVIs for coronavirus and search terms for pneumococcal and influenza vaccines.LimitationsSVIs estimate relative changes in online interest and do not represent the interest of people with no Internet access.ConclusionA peak in worldwide interest in pneumococcal and influenza vaccines coincided with the COVID-19 pandemic in February and March 2020. Trends are likely not seasonal in origin and may be driven by COVID-19 hotspots. Global events may change public perception about the importance of vaccines. Our findings may herald higher demand for pneumonia and influenza vaccines in the upcoming season.

Dataset Information

Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.

Publications

Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.

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