Oral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial.

ABSTRACT:

Introduction

Candida prophylaxis in ICU is still a matter of debate. Oral chemoprophylaxis has been advocated to reduce the incidence of Candida colonisation and infection.

Methods

We performed a randomised trial studying a single drug (nystatin) versus control in surgical/trauma ICU patients. Multiple-site testing for fungi was performed in each patient on ICU admission (T0) and subsequently every 3 days (T3, T6, T9, and so forth). The primary evaluation criterion was the time course of the corrected colonisation index.

Results

Ninety-nine patients were enrolled. At admission, 69 patients exhibited Candida colonisation: the most frequently colonised body sites were the stomach and the pharynx. The most frequent isolated species was Candida albicans. The corrected col

SUBMITTER: Giglio M 

PROVIDER: S-EPMC3681386 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature