Ontology highlight
ABSTRACT:
SUBMITTER: Gaziel-Sovran A
PROVIDER: S-EPMC3681522 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Gaziel-Sovran Avital A Segura Miguel F MF Di Micco Raffaella R Collins Mary K MK Hanniford Douglas D Vega-Saenz de Miera Eleazar E Rakus John F JF Dankert John F JF Shang Shulian S Kerbel Robert S RS Bhardwaj Nina N Shao Yongzhao Y Darvishian Farbod F Zavadil Jiri J Erlebacher Adrian A Mahal Lara K LK Osman Iman I Hernando Eva E
Cancer cell 20110701 1
To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that microRNAs can promote the evolution of malignant behaviors by regulating multiple targets. We performed a microRNA analysis of human melanoma, a highly invasive cancer, and found that miR-30b/30d upregulation correlates with stage, metastatic potential, shorter time to recurrence, and reduced overall survival. Ectopic expression of miR-30b/3 ...[more]