Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez MI
PROVIDER: S-EPMC3681683 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Rodríguez María Isabel MI Peralta-Leal Andreína A O'Valle Francisco F Rodriguez-Vargas José Manuel JM Gonzalez-Flores Ariannys A Majuelos-Melguizo Jara J López Laura L Serrano Santiago S de Herreros Antonio García AG Rodríguez-Manzaneque Juan Carlos JC Fernández Rubén R Del Moral Raimundo G RG de Almodóvar José Mariano JM Oliver F Javier FJ
PLoS genetics 20130613 6
PARP inhibition can induce anti-neoplastic effects when used as monotherapy or in combination with chemo- or radiotherapy in various tumor settings; however, the basis for the anti-metastasic activities resulting from PARP inhibition remains unknown. PARP inhibitors may also act as modulators of tumor angiogenesis. Proteomic analysis of endothelial cells revealed that vimentin, an intermediary filament involved in angiogenesis and a specific hallmark of EndoMT (endothelial to mesenchymal transit ...[more]