Ontology highlight
ABSTRACT:
SUBMITTER: Boeckmann L
PROVIDER: S-EPMC3681705 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Boeckmann Lars L Takahashi Yoshimitsu Y Au Wei-Chun WC Mishra Prashant K PK Choy John S JS Dawson Anthony R AR Szeto May Y MY Waybright Timothy J TJ Heger Christopher C McAndrew Christopher C Goldsmith Paul K PK Veenstra Timothy D TD Baker Richard E RE Basrai Munira A MA
Molecular biology of the cell 20130501 12
The centromeric histone H3 variant (CenH3) is essential for chromosome segregation in eukaryotes. We identify posttranslational modifications of Saccharomyces cerevisiae CenH3, Cse4. Functional characterization of cse4 phosphorylation mutants shows growth and chromosome segregation defects when combined with kinetochore mutants okp1 and ame1. Using a phosphoserine-specific antibody, we show that the association of phosphorylated Cse4 with centromeres increases in response to defective microtubul ...[more]