Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC3681775 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Liu Yang Y Quang Phong P Braggio Esteban E Ngo Hai H Badalian-Very Gayane G Flores Ludmila L Zhang Yong Y Sacco Antonio A Maiso Patricia P Azab Abdel Kareem AK Azab Feda F Carrasco Ruben R Rollins Barrett J BJ Roccaro Aldo M AM Ghobrial Irene M IM
PloS one 20130613 6
Glucocorticoid-induced TNF receptor (GITR) plays a crucial role in modulating immune response and inflammation, however the role of GITR in human cancers is poorly understood. In this study, we demonstrated that GITR is inactivated during tumor progression in Multiple Myeloma (MM) through promoter CpG island methylation, mediating gene silencing in primary MM plasma cells and MM cell lines. Restoration of GITR expression in GITR deficient MM cells led to inhibition of MM proliferation in vitro a ...[more]