Ontology highlight
ABSTRACT:
SUBMITTER: Beguelin W
PROVIDER: S-EPMC3681809 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Béguelin Wendy W Popovic Relja R Teater Matt M Jiang Yanwen Y Bunting Karen L KL Rosen Monica M Shen Hao H Yang Shao Ning SN Wang Ling L Ezponda Teresa T Martinez-Garcia Eva E Zhang Haikuo H Zheng Yupeng Y Verma Sharad K SK McCabe Michael T MT Ott Heidi M HM Van Aller Glenn S GS Kruger Ryan G RG Liu Yan Y McHugh Charles F CF Scott David W DW Chung Young Rock YR Kelleher Neil N Shaknovich Rita R Creasy Caretha L CL Gascoyne Randy D RD Wong Kwok-Kin KK Cerchietti Leandro L Levine Ross L RL Abdel-Wahab Omar O Licht Jonathan D JD Elemento Olivier O Melnick Ari M AM
Cancer cell 20130501 5
The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and targeted by somatic mutations in B cell lymphomas. Here, we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions. EZH2 represses proliferation checkpoint genes and helps establish bivalent chromatin domains at key regulatory loci to transiently suppress GC B cell differentiation. Somatic mutations reinforce these physiological effects through enhanced silencing of EZH2 ...[more]