Ontology highlight
ABSTRACT:
SUBMITTER: Garon EB
PROVIDER: S-EPMC3681857 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Garon Edward B EB Finn Richard S RS Hamidi Habib H Dering Judy J Pitts Sharon S Kamranpour Naeimeh N Desai Amrita J AJ Hosmer Wylie W Ide Susan S Avsar Emin E Jensen Michael Rugaard MR Quadt Cornelia C Liu Manway M Dubinett Steven M SM Slamon Dennis J DJ
Molecular cancer therapeutics 20130314 6
Heat shock protein 90 (HSP90) is involved in protein folding and functions as a chaperone for numerous client proteins, many of which are important in non-small cell lung cancer (NSCLC) pathogenesis. We sought to define preclinical effects of the HSP90 inhibitor NVP-AUY922 and identify predictors of response. We assessed in vitro effects of NVP-AUY922 on proliferation and protein expression in NSCLC cell lines. We evaluated gene expression changes induced by NVP-AUY922 exposure. Xenograft models ...[more]