Ontology highlight
ABSTRACT:
SUBMITTER: Gandre-Babbe S
PROVIDER: S-EPMC3682343 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Gandre-Babbe Shilpa S Paluru Prasuna P Aribeana Chiaka C Chou Stella T ST Bresolin Silvia S Lu Lin L Sullivan Spencer K SK Tasian Sarah K SK Weng Julie J Favre Helene H Choi John K JK French Deborah L DL Loh Mignon L ML Weiss Mitchell J MJ
Blood 20130425 24
Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm of young children initiated by mutations that deregulate cytokine receptor signaling. Studies of JMML are constrained by limited access to patient tissues. We generated induced pluripotent stem cells (iPSCs) from malignant cells of two JMML patients with somatic heterozygous p.E76K missense mutations in PTPN11, which encodes SHP-2, a nonreceptor tyrosine phosphatase. In vitro differentiation of JMML iPSCs produc ...[more]