Ontology highlight
ABSTRACT:
SUBMITTER: Vaishnav RA
PROVIDER: S-EPMC3682654 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Vaishnav Radhika A RA Liu Ruolan R Chapman Joab J Roberts Andrew M AM Ye Hong H Rebolledo-Mendez Jovan D JD Tabira Takeshi T Fitzpatrick Alicia H AH Achiron Anat A Running Mark P MP Friedland Robert P RP
Journal of neuroimmunology 20130509 1-2
Neuromyelitis optica (NMO) is associated with antibodies to aquaporin 4 (AQP4). We hypothesized that antibodies to AQP4 can be triggered by exposure to environmental proteins. We compared human AQP4 to plant and bacterial proteins to investigate the occurrence of significantly similar structures and sequences. High similarity to a known epitope for NMO-IgG, AQP4(207-232), was observed for corn ZmTIP4-1. NMO and non-NMO sera were assessed for reactivity to AQP4(207-232) and the corn peptide. NMO ...[more]