Ontology highlight
ABSTRACT:
SUBMITTER: Tanpure RP
PROVIDER: S-EPMC3682772 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
MedChemComm 20120601 6
The recent discovery of a small-molecule benzosuberene-based phenol that demonstrates remarkable picomolar cytotoxicity against selected human cancer cell lines and strongly inhibits tubulin polymerization (1-2 µM) inspired the design and synthesis of a variety of new, structurally diverse benzosuberene derivatives. An efficient synthetic route to functionalized benzosuberenes was developed. This methodology utilized a Wittig reaction, followed by a selective alkene reduction and ring-closing cy ...[more]