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Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors.

ABSTRACT: A series of self-immolative boronic ester protected methyl salicylates and metal-binding groups with various linking strategies have been investigated for their use in the design of matrix metalloproteinase proinhibitors.

SUBMITTER: Jourden JL 

PROVIDER: S-EPMC3682828 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors.

Jourden Jody L Major JL   Daniel Kevin B KB   Cohen Seth M SM  

Chemical communications (Cambridge, England) 20110616 28

A series of self-immolative boronic ester protected methyl salicylates and metal-binding groups with various linking strategies have been investigated for their use in the design of matrix metalloproteinase proinhibitors. ...[more]

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