Ontology highlight
ABSTRACT:
SUBMITTER: Muthusamy V
PROVIDER: S-EPMC3683103 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Muthusamy Viswanathan V Premi Sanjay S Soper Cara C Platt James J Bosenberg Marcus M
The Journal of investigative dermatology 20130130 7
Despite recent advancements in therapy, melanoma remains a highly lethal skin cancer. A better understanding of the genetic and epigenetic changes responsible for melanoma formation and progression could result in the development of more effective treatments. Advanced melanomas are known to exhibit widespread promoter region CpG island methylation leading to the inactivation of key tumor suppressor genes. Meta-analyses of relevant microarray data sets revealed the hematopoietic stem cell regulat ...[more]