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Lipid phosphate phosphatase (LPP3) and vascular development.

ABSTRACT: Lipid phosphate phosphatases (LPP) are integral membrane proteins with broad substrate specificity that dephosphorylate lipid substrates including phosphatidic acid, lysophosphatidic acid, ceramide 1-phosphate, sphingosine 1-phosphate, and diacylglycerol pyrophosphate. Although the three mammalian enzymes (LPP1-3) demonstrate overlapping catalytic activities and substrate preferences in vitro, the phenotypes of mice with targeted inactivation of the Ppap2 genes encoding the LPP enzymes reveal nonredundant functions. A specific role for LPP3 in vascular development has emerged from studies of mice lacking Ppap2b. A meta-analysis of multiple, large genome-wide association studies identified a single nucleotide polymorphism in PPAP2B as a novel predictor of coronary artery disease. In this review, we will discuss the evidence that links LPP3 to vascular development and disease and evaluate potential molecular mechanisms. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.

SUBMITTER: Ren H

PROVIDER: S-EPMC3683602 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Lipid phosphate phosphatase (LPP3) and vascular development.

Ren H H Panchatcharam M M Mueller P P Escalante-Alcalde D D Morris A J AJ Smyth S S SS

Biochimica et biophysica acta 20120724 1

Lipid phosphate phosphatases (LPP) are integral membrane proteins with broad substrate specificity that dephosphorylate lipid substrates including phosphatidic acid, lysophosphatidic acid, ceramide 1-phosphate, sphingosine 1-phosphate, and diacylglycerol pyrophosphate. Although the three mammalian enzymes (LPP1-3) demonstrate overlapping catalytic activities and substrate preferences in vitro, the phenotypes of mice with targeted inactivation of the Ppap2 genes encoding the LPP enzymes reveal no ...[more]

PMID: 22835522

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Anti-lipid phosphate phosphohydrolase-3 (LPP3) antibody inhibits bFGF- and VEGF-induced capillary morphogenesis of endothelial cells.

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| S-EPMC1201157 | biostudies-literature

Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development.

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| S-EPMC3196773 | biostudies-literature

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Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.

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| S-EPMC5157138 | biostudies-literature

Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis.

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| S-EPMC3944085 | biostudies-literature

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Lipid phosphatase SHIP-1 regulates chondrocyte hypertrophy and skeletal development.

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| S-EPMC3524385 | biostudies-literature

Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice.

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| S-EPMC4617140 | biostudies-literature

Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila.

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| S-EPMC2867317 | biostudies-literature

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