Ontology highlight
ABSTRACT:
SUBMITTER: Weekes MP
PROVIDER: S-EPMC3683642 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Weekes Michael P MP Tan Shireen Y L SY Poole Emma E Talbot Suzanne S Antrobus Robin R Smith Duncan L DL Montag Christina C Gygi Steven P SP Sinclair John H JH Lehner Paul J PJ
Science (New York, N.Y.) 20130401 6129
The reactivation of latent human cytomegalovirus (HCMV) infection after transplantation is associated with high morbidity and mortality. In vivo, myeloid cells and their progenitors are an important site of HCMV latency, whose establishment and/or maintenance require expression of the viral transcript UL138. Using stable isotope labeling by amino acids in cell culture-based mass spectrometry, we found a dramatic UL138-mediated loss of cell surface multidrug resistance-associated protein-1 (MRP1) ...[more]