Serotonin signaling in the brain of adult female mice is required for sexual preference.
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ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC3683771 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Serotonin signaling in the brain of adult female mice is required for sexual preference.
Zhang Shasha S Liu Yan Y Rao Yi Y
Proceedings of the National Academy of Sciences of the United States of America 20130528 24
A role for serotonin in male sexual preference was recently uncovered by our finding that male mutant mice lacking serotonin have lost sexual preference. Here we show that female mouse mutants lacking either central serotonergic neurons or serotonin prefer female over male genital odors when given a choice, and displayed increased female-female mounting when presented either with a choice of a male and a female target or only with a female target. Pharmacological manipulations and genetic rescue ...[more]
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