Ontology highlight
ABSTRACT:
SUBMITTER: Stettner P
PROVIDER: S-EPMC3683795 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Stettner Paula P Bourgeois Soline S Marsching Christian C Traykova-Brauch Milena M Porubsky Stefan S Nordström Viola V Hopf Carsten C Koesters Robert R Sandhoff Roger R Wiegandt Herbert H Wagner Carsten A CA Gröne Hermann-Josef HJ Jennemann Richard R
Proceedings of the National Academy of Sciences of the United States of America 20130528 24
Urinary ammonium excretion by the kidney is essential for renal excretion of sufficient amounts of protons and to maintain stable blood pH. Ammonium secretion by the collecting duct epithelia accounts for the majority of urinary ammonium; it is driven by an interstitium-to-lumen NH3 gradient due to the accumulation of ammonium in the medullary and papillary interstitium. Here, we demonstrate that sulfatides, highly charged anionic glycosphingolipids, are important for maintaining high papillary ...[more]