Ontology highlight
ABSTRACT:
SUBMITTER: Kurnellas MP
PROVIDER: S-EPMC3684024 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Kurnellas Michael P MP Adams Chris M CM Sobel Raymond A RA Steinman Lawrence L Rothbard Jonathan B JB
Science translational medicine 20130401 179
The amyloid-forming proteins tau, αB crystallin, and amyloid P protein are all found in lesions of multiple sclerosis (MS). Our previous work established that amyloidogenic peptides from the small heat shock protein αB crystallin (HspB5) and from amyloid β fibrils, characteristic of Alzheimer's disease, were therapeutic in experimental autoimmune encephalomyelitis (EAE), reflecting aspects of the pathology of MS. To understand the molecular basis for the therapeutic effect, we showed a set of am ...[more]