Dataset Information

Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT.

ABSTRACT:

Purpose

To determine whether choroidal imaging is feasible in preterm and term infants using an 840-nm portable spectral domain optical coherence tomography (SD-OCT) system without the use of enhanced-depth imaging techniques and to assess choroidal development by comparing choroidal thickness of preterm infants, term infants, and adults.

Methods

SD-OCT images were obtained from 86 preterm infants, 59 term infants, and nine adults using a portable SD-OCT system plus nine adults using a tabletop system. An unprocessed image across the macula from one randomly selected eye of each participant was selected for determination of whether the choroidal-scleral junction (CSJ) could be visualized and for measurement of choroidal thickness.

Results

Subfoveal CSJ was visualized in 96% of young-preterm infants (imaged from 30-36 weeks postmenstrual age [PMA]); 78% of term-aged preterm infants (imaged from 37-42 weeks PMA); 49% of term infants; and 39% of adult subjects. Racial pigmentation did not affect CSJ visibility in young-preterm infants (P = 0.57). Subfoveal choroidal thickness (SFCT) in young-preterm infants, term-aged preterm infants, term infants, and adults was 176 ± 53 ?m, 289 ± 92 ?m, 329 ± 66 ?m, and 258 ± 66 ?m, respectively, and these were all statistically significantly different from one another except term-aged preterms to adults.

Conclusions

Infant choroid can be imaged with a portable SD-OCT system without enhanced depth imaging. Melanin in the RPE and choroid does not hinder outer choroidal imaging in young-preterm infants without advanced retinopathy of prematurity (ROP). In preterm infants, choroidal thickness increased with age but was thinner when compared to term infants suggesting delayed development due to ROP.

SUBMITTER: Moreno TA

PROVIDER: S-EPMC3684216 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Publications

Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT.

Moreno Tomas A TA O'Connell Rachelle V RV Chiu Stephanie J SJ Farsiu Sina S Cabrera Michelle T MT Maldonado Ramiro S RS Tran-Viet Du D Freedman Sharon F SF Wallace David K DK Toth Cynthia A CA

Investigative ophthalmology & visual science 20130614 6

<h4>Purpose</h4>To determine whether choroidal imaging is feasible in preterm and term infants using an 840-nm portable spectral domain optical coherence tomography (SD-OCT) system without the use of enhanced-depth imaging techniques and to assess choroidal development by comparing choroidal thickness of preterm infants, term infants, and adults.<h4>Methods</h4>SD-OCT images were obtained from 86 preterm infants, 59 term infants, and nine adults using a portable SD-OCT system plus nine adults us ...[more]

PMID: 23652488

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Project description:OBJECTIVE: To assess the macular retina and choroidal thickness change in patients with obstructive sleep apnea-hypopnea syndrome (OSAS) with no significant symptoms and pathological changes in the fundus using spectral domain-optical coherence tomography. METHODS: This prospective, observational case-control study consisted of 53 eyes of 53 patients with OSAS and 12 eyes of 12 age-matched controls. Macular and choroidal thicknesses were measured by optical coherence tomography. RESULTS: The foveal and nasal macular thicknesses were significantly different between four groups (P=0.001, P=0.016). The foveal thickness of the control group was significantly thinner than that of the severe group (P=0.000). The nasal macular thickness of the control group was significantly thinner than that of the severe group (P=0.008). A significant correlation was found between oxygen desaturation index (ODI) and macular center thickness (r=0.357, R(2)=0.127, P=0.004), with an ODI coefficient of 0.457 (P=0.004). Similarly, a significant correlation was found between ODI and nasal macular thickness (r=0.265, R(2)=0.070, P=0.033), with an ODI coefficient of 0.233 (P=0.033). The subfoveal choroidal thickness was significantly different among the groups (F=3.657, P=0.017). The subfoveal choroidal thickness of the severe group was significantly thinner than that of the control group, mild group, and moderate group (P=0.023, 0.006, and 0.036, respectively). The choroidal thickness 1 mm nasal to the fovea was significantly different between the groups after correcting for age and diopter (F=3.411, P=0.023). The choroidal thickness 1 mm nasal to the fovea was significantly thinner in the severe group compared with the control group and mild group (P=0.013 and 0.010, respectively). Choroidal thickness was significantly correlated with diopter (r=0.520, R(2)=0.270, P<0.001), with a coefficient of 0.327 (P<0.001), and with ODI (r=0.520, R(2)=0.165, P=0.001), with a coefficient of -0.370 (P=0.001). CONCLUSIONS: OSAS patients showed decreased foveal and nasal macular thickness, similar to the subfoveal and nasal choroidal thickness. These findings suggest that, because of intermittent hypoxia, OSAS might change the retinal and choroidal blood supply.

Dataset Information

Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT.

Purpose

Methods

Results

Conclusions

Publications

Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT.

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