Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma.
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ABSTRACT:
SUBMITTER: Durie BG
PROVIDER: S-EPMC3684359 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma.
Durie B G M BG Van Ness B B Ramos C C Stephens O O Haznadar M M Hoering A A Haessler J J Katz M S MS Mundy G R GR Kyle R A RA Morgan G J GJ Crowley J J Barlogie B B Shaughnessy J J
Leukemia 20090806 10
Bone disease in myeloma occurs as a result of complex interactions between myeloma cells and the bone marrow microenvironment. A custom-built DNA single nucleotide polymorphism (SNP) chip containing 3404 SNPs was used to test genomic DNA from myeloma patients classified by the extent of bone disease. Correlations identified with a Total Therapy 2 (TT2) (Arkansas) data set were validated with Eastern Cooperative Oncology Group (ECOG) and Southwest Oncology Group (SWOG) data sets. Univariate corre ...[more]
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