Ontology highlight
ABSTRACT:
SUBMITTER: Du J
PROVIDER: S-EPMC3684423 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Du Jiamu J Kelly Alexander E AE Funabiki Hironori H Patel Dinshaw J DJ
Structure (London, England : 1993) 20120101 1
Survivin is an inhibitor of apoptosis family protein implicated in apoptosis and mitosis. In apoptosis, it has been shown to recognize the Smac/DIABLO protein. It is also a component of the chromosomal passenger complex, a key player during mitosis. Recently, Survivin was identified in vitro and in vivo as the direct binding partner for phosphorylated Thr3 on histone H3 (H3T3ph). We have undertaken structural and binding studies to investigate the molecular basis underlying recognition of H3T3ph ...[more]