SGK3 is associated with estrogen receptor expression in breast cancer.
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ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC3684450 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
SGK3 is associated with estrogen receptor expression in breast cancer.
Xu Jun J Wan Ma M He Quanyuan Q Bassett Roland L RL Fu Xiaoyong X Chen Albert C AC Shi Fengtao F Creighton Chad J CJ Schiff Rachel R Huo Lei L Liu Dan D
Breast cancer research and treatment 20120511 2
While breast cancer mortality rate has seen a steady decline in the last few decades, advances in better treatment and diagnostic tools remain important as we come into the age of personalized therapy. In this report, we describe our studies of SGK3's role in breast cancer. SGK3 (also known as CISK) is a member of the AGC family of kinases. Our previous work indicates that SGK3 functions downstream of the PI 3-kinase cascade and shares molecular and biochemical similarities with Akt. Here, we sh ...[more]
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